Irf8 t cell
WebIRF8 (interferon regulatory factor 8; OMIM 601565, Chr. 16) is a transcription factor that is exclusively found in cells with hematopoietic lineage and is highly expressed in …
Irf8 t cell
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WebApr 27, 2024 · CD8 + T cells are instrumental for the clearance of pathogen infected or malignant cells and the provision of immune memory. Upon T cell receptor (TCR) sensing of peptide presented by... WebMar 25, 2024 · High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer Abstract. Characterization of breast cancer (BC) through the determination of conventional markers such as ER, PR, …
WebDec 13, 2024 · IRF8 is a key regulator of early response pathways in myeloid cells, including phagosome maturation, antigen processing, and antigen presentation. Liver X receptor alpha binds the interferon regulatory factor 8 (IRF8) locus; its activation increases IRF8 mRNA and protein levels in macrophages IRF8 deficiency enhances TH17-cell differentiation. WebIRF8 (interferon regulatory factor 8; OMIM 601565, Chr. 16) is a transcription factor that is exclusively found in cells with hematopoietic lineage and is highly expressed in plasmacytoid dendritic cells ( Sichien et al., 2016 ).
WebApr 11, 2024 · IRF8 is an important regulatory gene for the development of dendritic cells, which play a crucial role in the regulation of insulin secretion and hyperglycemia (Besin et al., 2011). High glucose promotes dendritic cell maturation through activation of the NF-kB pathway, accelerating and amplifying the inflammatory immune response and ... WebFig. 2 Functionally specialized conventional and non-conventional dendritic cell subsets and related lineages. cDC1. cDC1起源于CD34+造血干细胞，分化过程受包括干扰素调节因子8 （IRF8）在内的转录因子组合的调节；具有独特的C型凝集素受体CLEC9A和趋化因子XCR1的 …
WebApr 14, 2024 · Antibodies against T-bet, p65, and IRF8 were purchased from Cell Signaling Technology, Inc. (Danvers, MA, USA). The nuclear and cytoplasmic isolation kit (Beyotime …
WebMar 23, 2024 · TFs like the interferon regulatory factor 8 (IRF8), inhibitor of DNA binding 2 (ID2), and nuclear factor interleukin 3-regulated (NFIL3) are required for the diversification of the common DC... is darth traya canonWebJan 26, 2024 · Thus, IRF8 expression in early T cell development is a distinct feature in humans. Fig. 1: TSP2- and HPC-annotated CD34+ human thymocytes express low levels of IRF8 and are bi-phenotypic... rwby hogwarts housesWebIndeed, IRF4 and IRF8 are required for early B cell development as homozygous compound-mutant mice exhibit a B cell developmental arrest at the pre-B cell stage (Lu et al., 2003). IRF4,8-deficient pre-B cells are highly proliferative, fail to downregulate the SLC components λ5 and VpreB, and display a severe impairment of Igκ rearrangement. rwby home away from homeWebMar 12, 2024 · The IRF8 signature co-segregated with T cell exhaustion markers and was negatively associated with long-term patient survival. Thus, CTL exhaustion is promoted by TAMs via IRF8, and this crosstalk ... rwby holocronWebNov 5, 2024 · IRF8 is not expressed in naive T cells, but is rapidly induced by T cell receptor (TCR) stimulation and γc-cytokine (30, 59), suggesting a role of IRF8 in T cell activation … rwby home fanfictionWebAug 24, 2024 · Human tumor cells may use the IRF8 promoter DNA methylation as a mechanism to repress IRF8 expression to advance cancer through acquiring apoptosis resistance and OPN up-regulation. Elevated OPN engages CD44 to suppress T cell activation and promote tumor cell stemness to advance cancer. rwby home lyricsWebJan 6, 2024 · Moreover, gene set enrichment analysis identified the interferon-gamma and PD-1 signaling signatures as the top suppressed pathways in patients with IRF8-low HCC. Contrarily, overexpression of IRF8 in HCC cells significantly enhanced antitumor effects in immune-competent mice, modulating infiltration of tumor-associated macrophages … is darth talon in kotor