Toxicokinetic profile 毒代动力学曲线
WebSep 23, 2024 · Compared to the known toxicokinetic profile of permethrin in male rats, female rats demonstrated a similar hepatic clearance but with a slower absorption rate. Indeed the estimated stomach intestine rate transfers (K si) in females were 2.3- and 3.6-fold lower compared to those in males for cis-and trans-permethrin, respectively. WebThe toxicokinetic profile in rabbits indicated the lower levels of glycolic acid was due to a slower rate of maternal metabolism of EG to glycolic acid, slow uptake of the metabolite …
Toxicokinetic profile 毒代动力学曲线
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WebMar 1, 1995 · Toxicokinetic (TK) studies are the basis for demonstrating dose-related drug exposure in animals and for ensuring that drug exposure is substantially greater in … WebApr 25, 2024 · Toxicokinetic models for the uptake of chemicals into fish are based on a number of processes for uptake and elimination. An overview of these processes is presented in Figure 1. ... In humans, the genetic complement of a person's CYP genes is highly relevant as to its drug metabolizing profile (see the section on Genetic variation in …
WebApr 28, 2024 · Toxicokinetics (TK) is defined as the generation of pharmacokinetic (PK) data, either as an integral component in the conduct of nonclinical toxicity studies or in … WebToxicokinetics refers to the movement and fate, also referred to as the disposition, of toxicants. The term is most commonly used when describing the time course of …
It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity. It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans. However, it can also be used in environmental risk assessments in order to determine the potential effects of releasing chemicals into the environment. In order to quantify toxic effects, t… WebToxicokinetic modeling may also be used as an aid in the development of biological exposure monitoring. The toxicokinetic model is then not used to calculate target doses …
WebJul 1, 2008 · The lack of significant impact of the tissue:blood partitioning for the fetus compartment on the toxicokinetic profile of the mother led us to arbitrarily give it the partition coefficient of the richly perfused tissues compartment. Metabolism is parameterized from half-life values for the compounds to be studied. This assumes that …
WebFeb 12, 2024 · The ability of the substance or it’s metabolites to pass through cell membranes and come into contact with specific cell components (e.g., DNA). The amount and duration of storage of the substance (or it’s metabolites) in body tissues. The rate and sites of excretion. Examples of how toxicokinetics of a substance can influence its toxicity: chocolate makers tree crosswordWebAug 1, 2011 · The simulated profile based on the maximum recommended dose was tested to approach the systemic level where the drug was anticipated not to cause significant toxic responses. ... However, the toxicity of the drug not only depends on the level, but also on the length of the exposure time. A toxicokinetic study might provide only the drug ... gray ankle socks for womenWebSep 1, 2024 · QF-036 exhibited a non-linear toxicokinetic profile over the dose range of 100-1000 mg/kg in the single dose study, and a saturation trend appeared at doses of 100 and 300 mg/kg. In the 4-week oral toxicity and toxicokinetic study, SD rats were given 0, 50, 100, and 200 mg/kg QF-036 once daily for 4 weeks, followed by a 4-week recovery period. chocolate maker\u0027s tree crosswordWebApr 3, 2024 · Toxicokinetic studies differ from pharmacokinetic studies primarily with respect to dose. The former is generally carried out at much higher doses than those used in pharmacokinetic studies. Data derived from toxicokinetic studies helps to assess the safety profile of a chemical agent at toxic dose levels while pharmacokinetic data is employed ... chocolate maker toy walmartWebUseful toxicokinetic data may be derived using a radiolabelled dose of the chemical, i.e. in which a proton in the molecule is replaced by a tritium atom or a carbon or sulfur atom is … gray ankle strap heels clark chryssaWebtoxicokinetic measurements. These measurement procedures may provide a means of obtaining multiple doses pharmacokinetic data in the test species, avoidance of … chocolate makers usaWebFeb 26, 2015 · Z-GP-Dox, the FAPα (fibroblast activation protein-α)-based doxorubicin prodrug, demonstrates excellent tumor targeting effects and a favorable toxicokinetic profile. However, the insoluble nature of Z-GP-Dox becomes a significant barrier to drug administration, particularly when it comes to the clin … gray anne